PSMD4/ASF anticorps (C-Term)

N° du produit ABIN1881698

Détail du produit anti-PSMD4/ASF anticorps

Antigène: PSMD4/ASF (Psmd4) (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4))

Épitope: AA 300-328, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMD4/ASF est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PSMD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-328 amino acids from the C-terminal region of human PSMD4.

Clone: RB41678

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-PSMD4/ASF (ABIN1881698)

Elangovan, Oh, Sukumaran, Wójcik, Yoo: "Functional differences between two major ubiquitin receptors in the proteasome; S5a and hRpn13." dans: Biochemical and biophysical research communications, Vol. 396, Issue 2, pp. 425-8, (2010) (PubMed).

Safadi, Shaw: "Differential interaction of the E3 ligase parkin with the proteasomal subunit S5a and the endocytic protein Eps15." dans: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1424-34, (2010) (PubMed).

Zhang, Wang, Ehlinger, Randles, Lary, Kang, Haririnia, Storaska, Cole, Fushman, Walters: "Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13." dans: Molecular cell, Vol. 35, Issue 3, pp. 280-90, (2009) (PubMed).

Kim, Kim, Uchiki, Gygi, Goldberg: "S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains." dans: The EMBO journal, Vol. 28, Issue 13, pp. 1867-77, (2009) (PubMed).

Gaurnier-Hausser, Tuszynski: "The immunomodulatory role of angiocidin, a novel angiogenesis inhibitor." dans: Current pharmaceutical design, Vol. 15, Issue 17, pp. 1937-48, (2009) (PubMed).

Détails sur PSMD4/ASF

Antigène: PSMD4/ASF (Psmd4) (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 4 (Psmd4))

Autre désignation: PSMD4 (Psmd4 Produits)

Synonymes: anticorps af-1, anticorps mcb1, anticorps pub-r5, anticorps rpn10, anticorps PSMD4, anticorps DDBDRAFT_0202512, anticorps DDBDRAFT_0232981, anticorps DDB_0202512, anticorps DDB_0232981, anticorps AF, anticorps AF-1, anticorps ASF, anticorps MCB1, anticorps Rpn10, anticorps S5A, anticorps pUB-R5, anticorps xrpn10c, anticorps Af1, anticorps Mcb1, anticorps angiocidin, anticorps im:6912672, anticorps psmd4, anticorps wu:fc68c04, anticorps zgc:110247, anticorps proteasome 26S subunit, non-ATPase 4, anticorps 26S proteasome non-ATPase regulatory subunit 4, anticorps 26s proteasome non-atpase regulatory subunit 4 (26s proteasomeregulatory subunit s5a), anticorps proteasome 26S subunit, non-ATPase 4 L homeolog, anticorps proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, anticorps proteasome 26S subunit, non-ATPase 4b, anticorps psmd4, anticorps PSMD4, anticorps LOC100194679, anticorps psmD4, anticorps LOC100283637, anticorps Smp_000740.1, anticorps psmd4.L, anticorps Psmd4, anticorps psmd4b

Sujet: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.

Poids moléculaire: 40737

NCBI Accession: NP_002801

UniProt: P55036

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway