UVRAG anticorps (C-Term)

N° du produit ABIN1882151

Détail du produit anti-UVRAG anticorps

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Épitope: AA 540-569, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UVRAG est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 540-569 amino acids from the C-terminal region of human UVRAG.

Clone: RB13045

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-UVRAG (ABIN1882151)

Wei: "Autophagic induction of amyotrophic lateral sclerosis-linked Cu/Zn superoxide dismutase 1 G93A mutant in NSC34 cells." dans: Neural regeneration research, Vol. 9, Issue 1, pp. 16-24, (2014) (PubMed).

Bodemann, Orvedahl, Cheng, Ram, Ou, Formstecher, Maiti, Hazelett, Wauson, Balakireva, Camonis, Yeaman, Levine, White: "RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly." dans: Cell, Vol. 144, Issue 2, pp. 253-67, (2011) (PubMed).

Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." dans: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, (2006) (PubMed).

Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: "Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997." dans: Cytogenetics and cell genetics, Vol. 79, Issue 1-2, pp. 1-20, (1998) (PubMed).

Détails sur UVRAG

Antigène: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Autre désignation: UVRAG (UVRAG Produits)

Synonymes: anticorps DHTX, anticorps VPS38, anticorps p63, anticorps 9530039D02Rik, anticorps AI648770, anticorps BB124205, anticorps Uvrag1, anticorps Uvragl, anticorps zgc:56164, anticorps uvrag, anticorps MGC81810, anticorps UVRAG, anticorps MGC131135, anticorps CG6116, anticorps Dmel\\CG6116, anticorps UV radiation resistance associated, anticorps UV radiation resistance associated gene, anticorps UV radiation resistance associated S homeolog, anticorps UV radiation resistance associated L homeolog, anticorps UV-resistance associated gene, anticorps UVRAG, anticorps Uvrag, anticorps uvrag, anticorps uvrag.S, anticorps uvrag.L

Sujet: UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving the UVAG gene are associated with left-right axis malformation and mutations in the gene have been associated with colon cancer.

Poids moléculaire: 78151

NCBI Accession: NP_003360

UniProt: Q9P2Y5