OTUD5 anticorps (C-Term)

N° du produit ABIN1886937

Détail du produit anti-OTUD5 anticorps

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the carboxy terminus of the human OTUD5.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur OTUD5

Antigène: OTUD5 (OTU Domain Containing 5 (OTUD5))

Autre désignation: OTUD5 (OTUD5 Produits)

Synonymes: anticorps DUBA, anticorps AA407879, anticorps AI553596, anticorps BB114028, anticorps DXImx46e, anticorps Sfc7, anticorps otud5, anticorps si:bz30i22.1, anticorps si:rp71-30i22.1, anticorps zgc:154072, anticorps wu:fi28a06, anticorps zgc:100839, anticorps OTU deubiquitinase 5, anticorps OTU domain containing 5, anticorps OTU deubiquitinase 5a, anticorps OTU deubiquitinase 5 S homeolog, anticorps OTU deubiquitinase 5 L homeolog, anticorps OTU deubiquitinase 5b, anticorps OTUD5, anticorps Otud5, anticorps otud5a, anticorps otud5.S, anticorps otud5.L, anticorps otud5b

Sujet: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily.The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein.Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses.It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus.Multiple isoforms of OTUD5 are known to exist.
Synonyms: OTU domain-containing protein 5, Deubiquitinating enzyme A, DUBA