S1PR1 anticorps (C-Term)

N° du produit ABIN1886995

Détail du produit anti-S1PR1 anticorps

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: At least two isoforms of S1P1 are known to exist, this S1P1 antibody will only recognize the shorter isoform.

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide near the carboxy terminus of the human S1P1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur S1PR1

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Autre désignation: S1P1 (S1PR1 Produits)

Synonymes: anticorps CD363, anticorps CHEDG1, anticorps D1S3362, anticorps ECGF1, anticorps EDG-1, anticorps EDG1, anticorps S1P1, anticorps AI849002, anticorps Edg1, anticorps Lpb1, anticorps S1p, anticorps S1p1, anticorps S1P receptor 1, anticorps S1P receptor Edg-1, anticorps edg1, anticorps etID43307.22, anticorps s1p1, anticorps wu:fb98f05, anticorps s1pr1, anticorps xts1p1, anticorps sphingosine-1-phosphate receptor 1, anticorps sphingosine-1-phosphate receptor 1 L homeolog, anticorps S1PR1, anticorps S1pr1, anticorps s1pr1, anticorps s1pr1.L

Sujet: Movement of lymphocytes through lymphoid organs is required for generating immunity.Their migration into lymph nodes follows a series of events including integrin activation through chemokine signaling, adhesion and diapedis.The release of lymphocytes from lymph nodes is regulated by the phospholipid sphingosine-1-phosphate (S1P).One of its receptors S1P1 binds S1P with highand affinity, agonism of this receptor by the immunosuppressive agent FTY720 inhibits the entry of tissue T cells into afferent lymphatics in homeostatic and inflammatory conditions.Recent experiments have indicated that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did and these cells where also less effectively retained after treatment with FTY720, and that egress competence could be restored by inactivating G alpha i-protein-coupled receptor signaling.These results suggest that S1P1 acts in the lymphocyte to promote lymph node egress by overcoming retention signals mediated by CCR7 and G alpha i-protein-coupled receptor signaling.
Synonyms: Sphingosine-1-phosphate receptor 1, S1PR1, EDG1, ECGF1

NCBI Accession: NP_001391

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2