SPINK7/ECRG2 anticorps (C-Term)

N° du produit ABIN1887135

Détail du produit anti-SPINK7/ECRG2 anticorps

Antigène: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPINK7/ECRG2 est non-conjugé

Application: ELISA, Western Blotting (WB)

Réactivité croisée (Details): ECRG2 antibody is predicted to not cross-react with other ECRG family members

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide near the carboxy terminus of human ECRG2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SPINK7/ECRG2

Antigène: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Autre désignation: ECRG2 (SPINK7 Produits)

Synonymes: anticorps Ecg2, anticorps Ecrg2, anticorps OM, anticorps ECG2, anticorps ECRG2, anticorps EG408198, anticorps serine peptidase inhibitor, Kazal type 7, anticorps serine peptidase inhibitor, Kazal type 7 (putative), anticorps Spink7, anticorps SPIK7, anticorps SPINK7

Sujet: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus.It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis.ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion.ECRG2 may thus represent a novel therapeutic target for cancer.
Synonyms: Esophageal cancer-susceptibility gene 2 protein, ECG2, serine protease inhibitor Kazal-type 7, SPINK7