NUMB anticorps (C-Term)
-
- Antigène Voir toutes NUMB Anticorps
- NUMB (Numb Homolog (NUMB))
-
Épitope
- C-Term
-
Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp NUMB est non-conjugé
-
Application
- Western Blotting (WB), ELISA
- Specificité
- At least four isoforms of NUMB are known to exist, this antibody will detect all of them.
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- 17 amino acid peptide near the carboxy terminus of human NUMB.
- Top Product
- Discover our top product NUMB Anticorps primaire
-
-
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- Conseil sur la manipulation
- Avoid freezing and thawing repeatly.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
-
- Antigène
- NUMB (Numb Homolog (NUMB))
- Autre désignation
- NUMB (NUMB Produits)
- Synonymes
- anticorps C14orf41, anticorps S171, anticorps c14_5527, anticorps Nb, anticorps NUMB, endocytic adaptor protein, anticorps numb homolog (Drosophila), anticorps NUMB, anticorps Numb, anticorps numb
- Sujet
-
NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells.NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2.NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
Synonyms: m-NUMB, S171 - NCBI Accession
- NP_1005743
- Pathways
- Cell-Cell Junction Organization
-