FBXL20 anticorps (C-Term)

N° du produit ABIN1887255

Détail du produit anti-FBXL20 anticorps

Antigène: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXL20 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 18 amino acid peptide near the carboxy terminus of the human SCRAPPER.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur FBXL20

Antigène: FBXL20 (F-Box and Leucine-Rich Repeat Protein 20 (FBXL20))

Autre désignation: SCRAPPER (FBXL20 Produits)

Synonymes: anticorps Fbl2, anticorps Fbl20, anticorps fbl20, anticorps MGC81000, anticorps scrapper, anticorps FBL2, anticorps 2610511F20Rik, anticorps 4632423N09Rik, anticorps AI849362, anticorps AL117906, anticorps C86145, anticorps Scr, anticorps mKIAA4147, anticorps FBXL2, anticorps Fbxl2, anticorps F-box and leucine rich repeat protein 20, anticorps F-box and leucine-rich repeat protein 20 L homeolog, anticorps F-box and leucine-rich repeat protein 20, anticorps F-box/LRR-repeat protein 20, anticorps putative fbxl20, anticorps F-box and leucine rich repeat protein 2, anticorps FBXL20, anticorps fbxl20.L, anticorps LOAG_14232, anticorps LOC100080065, anticorps Smp_097020.1, anticorps FBXL2, anticorps Fbxl20

Sujet: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif.SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane.Scrapper has orthologs in C.elegans, D.melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species.Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission.This identifies protein degradation as a mechanism for holding synaptic communication in check.
Synonyms: F-box, Leucine rich repeat protein 20, FBXL20, FBl2, FBL20

NCBI Accession: NP_116264