HUWE1 anticorps (C-Term)

N° du produit ABIN1887256

Détail du produit anti-HUWE1 anticorps

Antigène: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HUWE1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide from near the carboxy terminus of human ARF-BP1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur HUWE1

Antigène: HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))

Autre désignation: ARF-BP1 (HUWE1 Produits)

Synonymes: anticorps ARF-BP1, anticorps HECTH9, anticorps HSPC272, anticorps Ib772, anticorps LASU1, anticorps MULE, anticorps URE-B1, anticorps UREB1, anticorps 5430439H10Rik, anticorps AU041296, anticorps Arf-bp1, anticorps C430014N20Rik, anticorps C80292, anticorps Gm1718, anticorps Mule, anticorps Ureb1, anticorps HUWE1, anticorps si:dkey-242a8.2, anticorps Huwe1, anticorps mule, anticorps ib772, anticorps lasu1, anticorps ureb1, anticorps hecth9, anticorps arf-bp1, anticorps hspc272, anticorps HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase, anticorps HECT, UBA and WWE domain containing 1, anticorps E3 ubiquitin-protein ligase HUWE1, anticorps HUWE1, anticorps Huwe1, anticorps huwe1, anticorps LOC100123214, anticorps LOC100380641

Sujet: The ARF tumor suppressor is a critical regulator of p53 stability.In addition to p53, ARF1 binds to other proteins such as MDM2 and ARF-BP1, a large protein containing HECT, UBA and WWE motifs.ARF-BP1 directly binds and ubiquitinates p53, this activity is inhibited by ARF, indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF.ARF-BP1 can also catalyze the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis.Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein, resulting in an attenuation of apoptosis induced by DNA-damage agents.
Synonyms: ARF binding protein 1, HECT, UBA and WWE domain containing 1, HUWE1, Mcl-1 ubiquitin ligase E3, Mule

NCBI Accession: NP_113584