EI24 anticorps (C-Term)

N° du produit ABIN1887276

Détail du produit anti-EI24 anticorps

Antigène: EI24 (Etoposide Induced 2.4 (EI24))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EI24 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: At least two isoforms of EI24 are known to exist, this antibody will only detect the larger isoform.

Purification: Affinity chromatography purified via peptide column

Immunogène: 19 amino acid peptide near the carboxy terminus of human EI24.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur EI24

Antigène: EI24 (Etoposide Induced 2.4 (EI24))

Autre désignation: EI24 (EI24 Produits)

Synonymes: anticorps EPG4, anticorps PIG8, anticorps TP53I8, anticorps AA536736, anticorps AI115355, anticorps EI24, autophagy associated transmembrane protein, anticorps etoposide induced 2.4 mRNA, anticorps EI24, anticorps Ei24

Sujet: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor.EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER).It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2.EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness.Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
Synonyms: Etoposide-induced 24, PIG8, EPG4, TP53I8

NCBI Accession: NP_004870