Claudin 1 anticorps (C-Term)
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- Antigène Voir toutes Claudin 1 (CLDN1) Anticorps
- Claudin 1 (CLDN1)
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Épitope
- C-Term
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Claudin 1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- 20 amino acid peptide near the carboxy terminus of human CLDN1.
- Top Product
- Discover our top product CLDN1 Anticorps primaire
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- Conseil sur la manipulation
- Avoid freezing and thawing repeatly.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- Antigène
- Claudin 1 (CLDN1)
- Autre désignation
- CLDN1 (CLDN1 Produits)
- Synonymes
- anticorps CLD1, anticorps ILVASC, anticorps SEMP1, anticorps AI596271, anticorps cldn19, anticorps claudin-1, anticorps cld1, anticorps ilvasc, anticorps semp1, anticorps CLDN1, anticorps claudin 1, anticorps claudin 1 S homeolog, anticorps CLDN1, anticorps Cldn1, anticorps cldn1, anticorps cldn1.S
- Sujet
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Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands.Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells.They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity.Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent.Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer.Characterization of Claudins expression in human tumors can be an additional diagnostic tool.Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3.Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.
Synonyms: Claudin 1, CLD1, SEMP1, ILVASC, CLDN1 - Pathways
- Cell-Cell Junction Organization, Hepatitis C
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