BMF anticorps (C-Term)

N° du produit ABIN1887332

Détail du produit anti-BMF anticorps

Antigène: BMF (Bcl2 Modifying Factor (BMF))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BMF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogène: Bmf antibody was raised with a Synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human Bmf.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur BMF

Antigène: BMF (Bcl2 Modifying Factor (BMF))

Autre désignation: Bmf (BMF Produits)

Synonymes: anticorps BMF, anticorps AW260063, anticorps AW411872, anticorps Bcl2 modifying factor, anticorps Bcl2 modifying factor L homeolog, anticorps BCL2 modifying factor, anticorps BMF, anticorps bmf.L, anticorps Bmf

Sujet: Apoptosis is related to many diseases and development.Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death.Bcl-2 homology 3 (BH3) domain is a potent death domain.BH3-only proteins, including Bad, Bid, Bik, Hrk, Bim, Noxa, and PUMA, form a growing subclass of the Bcl-2 family.A novel BH3-only protein was recently identified in human and mouse and designated Bmf (for Bcl-2-modifing factor).The BH3 domain in Bmf is required both for binding to Bcl-2 proteins and for triggering apoptosis.In healthy cells, Bmf associates with the dynein light chain 2 (DLC2) component of the myosin V motors and is sequestered by the cell's actin cytoskeleton.Disruption of the actin cytoskeleton, either by depolymerization of actin filaments or by detachment of cells from the extracellular matrix, triggers release and activation of Bmf, initiating the downstream apoptotic program.Bmf is constitutively expressed in many tissues.

Poids moléculaire: 25 kDa

NCBI Accession: NP_277038