BICD2 anticorps (Center)

N° du produit ABIN1887500

Détail du produit anti-BICD2 anticorps

Antigène: BICD2 (Bicaudal D Homolog 2 (BICD2))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BICD2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée (Details): This BICD2 antibody will not cross-react with BICD1.

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide from near the center of human BICD2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur BICD2

Antigène: BICD2 (Bicaudal D Homolog 2 (BICD2))

Autre désignation: BICD2 (BICD2 Produits)

Synonymes: anticorps SMALED2, anticorps bA526D8.1, anticorps 0610027D24Rik, anticorps 1110005D12Rik, anticorps AA408834, anticorps mKIAA0699, anticorps MGC84972, anticorps BICD2, anticorps bicd2, anticorps BICD cargo adaptor 2, anticorps bicaudal D homolog 2 (Drosophila), anticorps BICD cargo adaptor 2 L homeolog, anticorps zgc:171572, anticorps BICD2, anticorps Bicd2, anticorps bicd2.L, anticorps bicd2, anticorps zgc:171572

Sujet: BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis.Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin.The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles.Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients.
Synonyms: Bicaudal D homolog 2

Pathways: Maintenance of Protein Location