MAP1 anticorps (Center)

N° du produit ABIN1887547

Détail du produit anti-MAP1 anticorps

Antigène: MAP1 (Mannosidase Processing 1 (MAP1))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP1 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogène: 15 amino acid peptide from near the center of human MAP-1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur MAP1

Antigène: MAP1 (Mannosidase Processing 1 (MAP1))

Autre désignation: MAP1 (MAP1 Produits)

Synonymes: anticorps Map-1, anticorps Map1, anticorps mannosidase processing 1, anticorps Blood pressure QTL 196, anticorps Map1, anticorps Bp196

Sujet: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.Disruption of this process has been implicated in a variety of diseases such as cancer.Members of the Bcl-2 family are known to be critical regulators of this process.These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains.A related protein termed MAP-1 has recently been identified.This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed.It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo.It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

NCBI Accession: NP_071434

Pathways: Positive Regulation of Endopeptidase Activity