PTRH2 anticorps (Center)

N° du produit ABIN1887581

Détail du produit anti-PTRH2 anticorps

Antigène: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTRH2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide from near the center of human Bit1.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur PTRH2

Antigène: PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))

Autre désignation: Bit1 (PTRH2 Produits)

Synonymes: anticorps BIT1, anticorps PTH2, anticorps A230072I16Rik, anticorps Bit1, anticorps CGI-147, anticorps wu:fj09f02, anticorps zgc:109954, anticorps RGD1306819, anticorps peptidyl-tRNA hydrolase 2, anticorps ptrh2, anticorps CC1G_10259, anticorps ANI_1_1036184, anticorps AOR_1_2082154, anticorps PTRH2, anticorps Ptrh2

Sujet: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading.Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment.Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process.Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis.Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination.It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE.Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
Synonyms: Bcl-2 inhibitor of transcription 1, Peptidyl-tRNA hydrolase 2

NCBI Accession: NP_057161