Syntaphilin anticorps (Center)

N° du produit ABIN1887607

Détail du produit anti-Syntaphilin anticorps

Antigène: Syntaphilin (SNPH)

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Syntaphilin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide from near the center of human Syntaphilin.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur Syntaphilin

Antigène: Syntaphilin (SNPH)

Autre désignation: Syntaphilin (SNPH Produits)

Synonymes: anticorps bA314N13.5, anticorps 6430515A01, anticorps AW045671, anticorps AW556958, anticorps AW743098, anticorps mKIAA0374, anticorps syntaphilin, anticorps SNPH, anticorps Snph

Sujet: Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait.Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25.Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis.Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis.Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria.This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function.Multiple isoforms are known to exist.
Synonyms: SNPH

UniProt: O15079

Pathways: Synaptic Vesicle Exocytosis