MED28 anticorps (Center)

N° du produit ABIN1887640

Détail du produit anti-MED28 anticorps

Antigène: MED28 (Mediator Complex Subunit 28 (MED28))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MED28 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Purification: Affinity chromatography purified via peptide column

Immunogène: 17 amino acid peptide from near the center of human MED28.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur MED28

Antigène: MED28 (Mediator Complex Subunit 28 (MED28))

Autre désignation: MED28 (MED28 Produits)

Synonymes: anticorps 1500003D12Rik, anticorps EG1, anticorps magicin, anticorps Eg1, anticorps FKSG20, anticorps RGD1305875, anticorps wu:fc74b11, anticorps zgc:103633, anticorps AI451633, anticorps AU045690, anticorps mediator complex subunit 28, anticorps MED28, anticorps Med28, anticorps med28

Sujet: The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor.One of the proteins in this complex is MED28, also known as Magicin.MED28 is expressed in many cell lines and tissues.It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes.MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity.MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment.At least two isoforms of MED28 are known to exist.
Synonyms: Mediator of RNA polymerase II transcription subunit 28, magicin, EG1

NCBI Accession: NP_079481

Pathways: Stem Cell Maintenance, Regulation of Muscle Cell Differentiation