KPNA6 anticorps (N-Term)

N° du produit ABIN1887843

Détail du produit anti-KPNA6 anticorps

Antigène: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA6 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the amino terminus of human KPNA6.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur KPNA6

Antigène: KPNA6 (Karyopherin alpha 6 (Importin alpha 7) (KPNA6))

Autre désignation: KPNA6 (KPNA6 Produits)

Synonymes: anticorps IPOA7, anticorps Kpna5, anticorps NPI-2, anticorps KPNA7, anticorps karyopherin subunit alpha 6, anticorps karyopherin (importin) alpha 6, anticorps karyopherin alpha 6 (importin alpha 7), anticorps karyopherin alpha 6 (importin alpha 7) S homeolog, anticorps KPNA6, anticorps Kpna6, anticorps kpna6.S

Sujet: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism.The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC.KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6.Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation.KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
Synonyms: Karyopherin alpha nucleoprotein interactor 6, Importin alpha 7, IPOA7

Pathways: Protein targeting to Nucleus