SKI anticorps (N-Term)

N° du produit ABIN1887862

Détail du produit anti-SKI anticorps

Antigène: SKI (SKI Proto-Oncogene (SKI))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKI est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Purification: Affinity chromatography purified via peptide column

Immunogène: 14 amino acid peptide from near the amino terminus of human Ski.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SKI

Antigène: SKI (SKI Proto-Oncogene (SKI))

Autre désignation: Ski (SKI Produits)

Synonymes: anticorps SGS, anticorps SKV, anticorps SKI, anticorps C-SKI, anticorps RGD1565591, anticorps c-ski, anticorps 2310012I02Rik, anticorps 2610001A11Rik, anticorps AA062172, anticorps AA589460, anticorps BC004088, anticorps ski, anticorps skv, anticorps xski, anticorps id:ibd1250, anticorps SKI proto-oncogene, anticorps ski sarcoma viral oncogene homolog (avian), anticorps SKI proto-oncogene L homeolog, anticorps v-ski avian sarcoma viral oncogene homolog a, anticorps SKI, anticorps Ski, anticorps ski.L, anticorps skia

Sujet: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis.This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN.Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes.Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
Synonyms: c-ski, v-ski sarcoma viral oncogene homolog

UniProt: P12755

Pathways: Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development