CXXC4 anticorps (N-Term)

N° du produit ABIN1888157

Détail du produit anti-CXXC4 anticorps

Antigène: CXXC4 (CXXC Finger Protein 4 (CXXC4))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CXXC4 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogène: CXXC4 antibody was raised against an 18 amino acid peptide near the amino terminus of human CXXC4.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur CXXC4

Antigène: CXXC4 (CXXC Finger Protein 4 (CXXC4))

Autre désignation: CXXC4 (CXXC4 Produits)

Synonymes: anticorps 9330210J02Rik, anticorps C030003J12Rik, anticorps Idax, anticorps IDAX, anticorps Xldax, anticorps xIdax, anticorps CXXC finger 4, anticorps CXXC finger protein 4, anticorps CXXC finger protein 4 S homeolog, anticorps Cxxc4, anticorps CXXC4, anticorps cxxc4.S

Sujet: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region.CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN.In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin.Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
Synonyms: CXXC-type zinc finger protein 4, IDAX

NCBI Accession: NP_079488