PAWR anticorps

N° du produit ABIN1944911

Détail du produit anti-PAWR anticorps

Antigène: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAWR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-PAWR (ABIN1944911)

Chakraborty, Qiu, Vasudevan, Rangnekar: "Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression." dans: Cancer research, Vol. 61, Issue 19, pp. 7255-63, (2001) (PubMed).

Chang, Kim, Shin: "p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition." dans: FEBS letters, Vol. 510, Issue 1-2, pp. 57-61, (2001) (PubMed).

Johnstone, See, Sells, Wang, Muthukkumar, Englert, Haber, Licht, Sugrue, Roberts, Rangnekar, Shi: "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1." dans: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6945-56, (1997) (PubMed).

Détails sur PAWR

Antigène: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Abstract: PAWR Produits

Synonymes: anticorps MGC81382, anticorps pawrl, anticorps zgc:103513, anticorps PAWR, anticorps PAR4, anticorps Par-4, anticorps Par4, anticorps 2310001G03Rik, anticorps pro-apoptotic WT1 regulator, anticorps PRKC, apoptosis, WT1, regulator L homeolog, anticorps PRKC, apoptosis, WT1, regulator, anticorps PAWR, anticorps pawr.L, anticorps pawr, anticorps Pawr

Sujet: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Poids moléculaire: 36568 Da

ID gène: 5074

UniProt: Q96IZ0