Cyclin D2 anticorps
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- Antigène Voir toutes Cyclin D2 (CCND2) Anticorps
- Cyclin D2 (CCND2)
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Cyclin D2 est non-conjugé
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Application
- Western Blotting (WB)
- Isotype
- IgG
- Top Product
- Discover our top product CCND2 Anticorps primaire
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- Indications d'application
- WB: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- Stock
- 4 °C,-20 °C
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Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines." dans: Oncogene, Vol. 8, Issue 4, pp. 1049-54, (1993) (PubMed).
: "Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins." dans: Genomics, Vol. 13, Issue 3, pp. 575-84, (1992) (PubMed).
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Cyclins D1 and D2 are differentially expressed in human B-lymphoid cell lines." dans: Oncogene, Vol. 8, Issue 4, pp. 1049-54, (1993) (PubMed).
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- Antigène
- Cyclin D2 (CCND2)
- Autre désignation
- Cyclin D2 (CCND2 Produits)
- Synonymes
- anticorps si:ch211-240j22.2, anticorps ccnd2, anticorps CCND2, anticorps kiak0002, anticorps zgc:162280, anticorps LOC100224096, anticorps KIAK0002, anticorps BF642806, anticorps C86853, anticorps Vin-1, anticorps Vin1, anticorps cD2, anticorps 2600016F06Rik, anticorps AI256817, anticorps cyclin D2, b, anticorps cyclin D2 S homeolog, anticorps cyclin D2, anticorps G1/S-specific cyclin-D2, anticorps cyclin D2, a, anticorps cyclin D2 L homeolog, anticorps ccnd2b, anticorps ccnd2.S, anticorps CCND2, anticorps ccnd2, anticorps ccnd2a, anticorps Ccnd2, anticorps ccnd2.L
- Sujet
- Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
- Poids moléculaire
- 33067 Da
- ID gène
- 894
- UniProt
- P30279
- Pathways
- Cycle Cellulaire, Mitotic G1-G1/S Phases
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