BRE anticorps

N° du produit ABIN1944961

Détail du produit anti-BRE anticorps

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRE est non-conjugé

Application: Western Blotting (WB)

Isotype: IgG

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-BRE (ABIN1944961)

Dong, Hakimi, Chen, Kumaraswamy, Cooch, Godwin, Shiekhattar: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." dans: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).

Ching, Li, Li, Chan, Chan, Lim, Pang, Chui: "Expression of human BRE in multiple isoforms." dans: Biochemical and biophysical research communications, Vol. 288, Issue 3, pp. 535-45, (2001) (PubMed).

Li, Yoo, Becker, Ali-Osman, Chan: "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." dans: Biochemical and biophysical research communications, Vol. 206, Issue 2, pp. 764-74, (1995) (PubMed).

Détails sur BRE

Antigène: BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))

Autre désignation: BRE (BRE Produits)

Synonymes: anticorps brcc4, anticorps brcc45, anticorps BRE, anticorps LOC100231620, anticorps BRCC4, anticorps BRCC45, anticorps 6030405P19Rik, anticorps AI429776, anticorps B830038C02Rik, anticorps im:7141046, anticorps zgc:110368, anticorps BRISC and BRCA1 A complex member 2, anticorps brain and reproductive organ-expressed (TNFRSF1A modulator), anticorps BRISC and BRCA1 A complex member 2 L homeolog, anticorps babam2, anticorps BABAM2, anticorps Babam2, anticorps BRE, anticorps babam2.L

Sujet: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.

Poids moléculaire: 43552 Da

ID gène: 9577

UniProt: Q9NXR7

Pathways: Positive Regulation of Response to DNA Damage Stimulus