CD79a anticorps (AA 208-222) (APC)
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- Antigène Voir toutes CD79a (CD79A) Anticorps
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
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Épitope
- AA 208-222
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Reactivité
- Humain, Souris, Rat, Boeuf (Vache), Porc, Poulet, Cheval, Lapin, Cobaye, Chien, Non-Human Primate
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD79a est conjugé à/à la APC
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Application
- Flow Cytometry (FACS)
- Specificité
- The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- Réactivité croisée (Details)
- Human, Non-Human Primates, Porcine, Mouse, Rat, Bovine, Canine (Dog), Equine (Horse), Guinea pig, Rabbit, Chicken
- Purification
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Immunogène
- Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
- Clone
- HM47
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product CD79A Anticorps primaire
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- Indications d'application
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Intracellular staining.
- Commentaires
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The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- Restrictions
- For Research Use only
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- Buffer
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
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Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user. - Stock
- 4 °C
- Stockage commentaire
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." dans: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
: "CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner." dans: American journal of clinical pathology, Vol. 128, Issue 2, pp. 306-13, (2007) (PubMed).
: "Immunohistochemical and histochemical stains for differentiating canine cutaneous round cell tumors." dans: Veterinary pathology, Vol. 42, Issue 4, pp. 437-45, (2005) (PubMed).
: "Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein-Barr virus." dans: Journal of virology, Vol. 78, Issue 24, pp. 13891-900, (2004) (PubMed).
: "B-cell markers in lymphocyte predominance Hodgkin disease." dans: Archives of pathology & laboratory medicine, Vol. 126, Issue 7, pp. 862-3, (2002) (PubMed).
: "Expression of Ig-beta (CD79b) by chronic lymphocytic leukemia B cells that lack immunoglobulin heavy-chain allelic exclusion." dans: Blood, Vol. 95, Issue 8, pp. 2725-7, (2000) (PubMed).
: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).
: "
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C-MYC rearrangements are frequent in aggressive mature B-Cell lymphoma with atypical morphology." dans: International journal of clinical and experimental pathology, Vol. 1, Issue 1, pp. 65-74, (2008) (PubMed).
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- Antigène
- CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
- Autre désignation
- CD79a (CD79A Produits)
- Synonymes
- anticorps CD79A, anticorps Ig-alpha, anticorps Iga, anticorps Igalpha, anticorps Ly-54, anticorps Ly54, anticorps mb-1, anticorps IGA, anticorps MB-1, anticorps IG-alpha, anticorps CD79a molecule, anticorps CD79A antigen (immunoglobulin-associated alpha), anticorps Cd79a molecule-like, anticorps CD79A, anticorps Cd79a, anticorps Cd79al
- Sujet
- CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
- ID gène
- 973
- UniProt
- P11912
- Pathways
- BCR Signaling
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