IL4 Receptor anticorps (Extracellular Domain)

N° du produit ABIN198262

Cet anticorps Souris Monoclonal détecte spécifiquement IL4 Receptor dans WB, ELISA, IHC, FACS et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour IL4 Receptor anticorps (Extracellular Domain) (ABIN198262)

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL4 Receptor est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 49-20

Détail du produit anti-IL4 Receptor anticorps

Épitope: Extracellular Domain

Specificité: Recognizes human Interleukin-4 receptor subunit alpha, also known as CD124. CD124 is a 825 amino acid ~90kD type I single pass transmembrane glycoprotein bearing a single domain. Interleukin-4 Receptor form a heterodimeric complex with the, referred to as the IL-4 type-1 complex. The alpha subunit can also form the type-II complex through association with the IL-13 receptor alpha 1 subunit. The IL-4R complex acts as a receptor for both interleukin-4 and interleukin-13. IL-4 R is expressed by B cells, T cells, monocytes and macrophages. Is reported to block human cell surface IL-4 receptor mediated bioactivities induced by IL-4 or IL-13. An ND50 was observed at approximately 5-20 ng/mL in the presence of 0.2 ng/mL of IL-4 using the factor dependant human erythroleukemic cell line, TF-1.

Purification: Protein A purified

Immunogène: Sf 21-derived, recombinant human interleukin 4 receptor, extracellular domain.

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA (1:500 - 1:2000), Flo (1:20 - 1:80), IHC, IHC-P (1:40 - 1:125), WB (1:250 - 1:1000)

Usage: Western Blot: Will detect human IL-4 R under non-reducing conditions.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 10 % trehalose

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Détails sur IL4 Receptor

Antigène: IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))

Autre désignation: IL4R / CD124

Sujet: Name/Gene ID: IL4R
Family: Interleukin

Synonyms: IL4R, CD124, CD124 antigen, IL-4RA, IL4R nirs variant 1, IL4RA, Interleukin 4 receptor, IL-4 receptor subunit alpha, IL-4R subunit alpha, IL-4R-alpha

ID gène: 3566

Pathways: Signalistation JAK/STAT, Positive Regulation of Immune Effector Process