CD300a anticorps
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- Antigène Voir toutes CD300a (CD300A) Anticorps
- CD300a (CD300A)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD300a est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Specificité
- Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
- Purification
- Protein A purified
- Immunogène
- Human HPB acute lymphoid leukaemia cell line.
- Clone
- MEM-260
- Isotype
- IgG1
- Top Product
- Discover our top product CD300A Anticorps primaire
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- Indications d'application
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Approved: Flo, WB
Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. Western Blot: LS-C45034 detects a band of approximately 60kD in HPB cell lysates under non-reducing conditions. - Commentaires
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4, 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Antigène
- CD300a (CD300A)
- Autre désignation
- CD300A (CD300A Produits)
- Synonymes
- anticorps CD300L-B1, anticorps CD300A, anticorps clm8, anticorps B230315M08Rik, anticorps Clm8, anticorps LMIR1, anticorps MAIR-I, anticorps MAIR-Ia, anticorps MMAC8, anticorps Pigr4, anticorps mcpir1, anticorps CLM-8, anticorps CMRF-35-H9, anticorps CMRF-35H, anticorps CMRF35-H, anticorps CMRF35-H9, anticorps CMRF35H, anticorps CMRF35H9, anticorps IGSF12, anticorps IRC1, anticorps IRC1/IRC2, anticorps IRC2, anticorps IRp60, anticorps CD300 molecule like family member g, anticorps CD300a molecule, anticorps CMRF35-like molecule 8, anticorps CD300A molecule, anticorps Cd300a molecule, anticorps CD300LG, anticorps CD300A, anticorps LOC483289, anticorps clm8, anticorps Cd300a
- Sujet
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Name/Gene ID: CD300A
Synonyms: CD300A, CD300a antigen, CD300a molecule, CMRF35-like molecule 8, CMRF35-H, CMRF35-H9, CLM-8, CMRF35H9, IGSF12, Inhibitory receptor protein 60, IRC2, IRC1, NK inhibitory receptor, CMRF-35-H9, CMRF-35H, CMRF35H, IRC1a, IRp60, Leukocyte membrane antigen - ID gène
- 11314
- UniProt
- Q9UGN4
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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