VIPR1 anticorps (AA 151-250) (Alexa Fluor 350)

N° du produit ABIN2178783

Détail du produit anti-VIPR1 anticorps (Alexa Fluor 350)

Antigène: VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))

Épitope: AA 151-250

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VIPR1 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human GPCR RDC1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur VIPR1

Antigène: VIPR1 (Vasoactive Intestinal Peptide Receptor 1 (VIPR1))

Autre désignation: Rdc1 (VIPR1 Produits)

Synonymes: anticorps HVR1, anticorps II, anticorps PACAP-R-2, anticorps PACAP-R2, anticorps RDC1, anticorps V1RG, anticorps VAPC1, anticorps VIP-R-1, anticorps VIPR, anticorps VIRG, anticorps VPAC1, anticorps VPAC1R, anticorps VPCAP1R, anticorps CVIPR, anticorps AV071699, anticorps VIP-R1, anticorps RATVASREC, anticorps VASREC, anticorps VIPR1, anticorps LOC100226500, anticorps vipr1, anticorps hvr1, anticorps rdc1, anticorps v1rg, anticorps vipr, anticorps virg, anticorps vapc1, anticorps vpac1, anticorps vpcap1, anticorps vpac1-r, anticorps VIP-R, anticorps vasoactive intestinal peptide receptor 1, anticorps vasoactive intestinal peptide receptor 1b, anticorps vasoactive intestinal peptide receptor 1 S homeolog, anticorps vasoactive intestinal polypeptide receptor, anticorps VIPR1, anticorps Vipr1, anticorps vipr1b, anticorps vipr1, anticorps vipr1.S, anticorps LOC100303683

Sujet:

Synonyms: C-X-C chemokine receptor type 7, Chemokine orphan receptor 1, CMKOR1, CXC-R7, CXCR-7, CXCR7, G-protein coupled receptor 159, G-protein coupled receptor RDC1 homolog, GPR159, RDC-1, RDC1, CXCR7_HUMAN, ACKR3

Background: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates

ID gène: 57007

UniProt: P25106