BPI anticorps

N° du produit ABIN2191911

Détail du produit anti-BPI anticorps

Antigène: BPI (Bactericidal/Permeability Increasing Protein (BPI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BPI est non-conjugé

Application: Immunoassay (IA)

Stérilité: 0.2 μm filtered

Clone: 4H5

Information d'application

Indications d'application: The monoclonal antibody 4H5 can be used for immuno assays both as coating and as detector.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Détails sur BPI

Antigène: BPI (Bactericidal/Permeability Increasing Protein (BPI))

Autre désignation: Bactericidal Permeability Increasing Protein (BPI Produits)

Synonymes: anticorps 9230105K17Rik, anticorps Bpifd1, anticorps BPIFD1, anticorps rBPI, anticorps bpi, anticorps bpi.L, anticorps lbp, anticorps bactericidal/permeability-increasing protein, anticorps bactericidal permeablility increasing protein, anticorps bactericidal/permeability-increasing protein S homeolog, anticorps BPI, anticorps Bpi, anticorps bpi.S

Sujet: The monoclonal antibody 4H5 reacts specifically with full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21 kDa bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage against invasive pneumococcal disease by binding to the gram-positive bacterial pathogen, pneumolysin. The monoclonal antibody 4H5 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.