Neutrophil Lipocalin , Ngal anticorps

N° du produit ABIN2192048

Détail du produit

Antigène: Neutrophil Lipocalin , Ngal

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Application: Immunoassay (IA), Immunofluorescence (IF)

Stérilité: 0.2 μm filtered

Clone: 697

Information d'application

Indications d'application: For immunofluorescence dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Référence

Metso, Venge, Haahtela, Peterson, Sevéus: "Cell specific markers for eosinophils and neutrophils in sputum and bronchoalveolar lavage fluid of patients with respiratory conditions and healthy subjects." dans: Thorax, Vol. 57, Issue 5, pp. 449-51, (2002) (PubMed).

Détail du antigène

Antigène: Neutrophil Lipocalin , Ngal

Synonymes: anticorps 24p3, anticorps MSFI, anticorps NGAL, anticorps lipocalin 2, anticorps LCN2

Sujet: The monoclonal antibody 697 reacts with human neutrophil lipocalin (HNL), also known as human nGAL (25 kDa). Lipocalins are a widespread family of small, robust proteins that typically transport or store biological compounds which are either of low solubility or are chemically sensitive, including vitamins, steroids, odorants and metabolic products. The members of this lipocalins share a high similarity in their tertiary structures in spite of a low degree in amino-acid sequence identity: three highly conserved sequence motifs form a funnel-like beta barrel which encloses a hydrophobic pocket for the internal ligand binding. The human neutrophil lipocalin (HNL) is produced by neutrophil leukocytes and stored in intracellular specific granules. Neutrophil lipocalin is covalently linked to gelatinase B (MMP-9) and proMMP is stored in three forms: the monomeric form (92 kDa), the homodimer (220 kDa) and a heterodimer (125 kDa). During inflammation and neoplastic transformation the human neutrophil lipocalin (HNL) is produced in neutrophils and in epithelial cells. Furthermore neutrophil lipocalin is a superior means to distinguish acute bacterial and viral infections as well as it enables the determination of the neutrophil activation level.