Benzo[a]pyrenediol Epoxide anticorps

N° du produit ABIN2192144

Détail du produit anti-Benzo[a]pyrenediol Epoxide anticorps

Antigène: Benzo[a]pyrenediol Epoxide (BPDE)

Reactivité: Chemical

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Benzo[a]pyrenediol Epoxide est non-conjugé

Application: Immunoassay (IA), Immunoprecipitation (IP)

Stérilité: 0.2 μm filtered

Clone: 8E11

Information d'application

Indications d'application: The monoclonal antibody 8E11 can be used for immuno purification and for immuno assays as detector.

Restrictions: For Research Use only

Stockage

Buffer: PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Date de péremption: 12 months

Références pour anticorps anti-Benzo[a]pyrenediol Epoxide (ABIN2192144)

Santella, Gammon, Zhang, Motykiewicz, Young, Hayes, Terry, Schoenberg, Brinton, Bose, Teitelbaum, Hibshoosh: "Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue." dans: Cancer letters, Vol. 154, Issue 2, pp. 143-9, (2000) (PubMed).

Mumford, Williams, Wilcosky, Everson, Young, Santella: "A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues." dans: Mutation research, Vol. 359, Issue 3, pp. 171-7, (1996) (PubMed).

Santella, Lin, Cleveland, Weinstein: "Monoclonal antibodies to DNA modified by a benzo[a]pyrene diol epoxide." dans: Carcinogenesis, Vol. 5, Issue 3, pp. 373-7, (1984) (PubMed).

Détails sur Benzo[a]pyrenediol Epoxide

Antigène: Benzo[a]pyrenediol Epoxide (BPDE)

Abstract: BPDE Produits

Classe de substances: Chemical

Sujet: A number of chemicals, including polycyclic aromatic hydrocarbons (PAHs), have been shown to bind to DNA. This DNA damage can occur both early and late in the malignant process, thereby acting as an initiator and assisting in the progression of tumors. PAHs are released into the environment following incomplete combustion of organic materials. The most common sources of PAHs are from smoking and from consuming broiled or grilled foods. Human exposure to PAHs comes from various occupational, environmental, dietary and medicinal sources. Benzo[a]pyrene is a representitive PAH. Antibodies to benzo[a]pyrenediol-epoxide modified DNA (BPDE-DNA) can be used to identify polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Exposure to this group of compounds is believed to be carcinogenic. The monoclonal antibody 8E11 recognizes free BPDE and DNA adducts.