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Tamalin/GRASP anticorps

GRASP Reactivité: Souris IP, ELISA, WB Hôte: Lapin Polyclonal unconjugated
Pubmed (4 références)
N° du produit ABIN233820
$658.50
Plus frais de port $45.00 et $20.00 pour carboglace
100 μg
Destination: Etats-Unis
Envoi sous 1 à 2 jours ouvrables
  • Antigène Voir toutes Tamalin/GRASP (GRASP) Anticorps
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    Reactivité
    • 17
    • 16
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 18
    Lapin
    Clonalité
    • 18
    Polyclonal
    Conjugué
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp Tamalin/GRASP est non-conjugé
    Application
    • 9
    • 3
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), ELISA, Western Blotting (WB)
    Attributs du produit
    Concentration Definition: by UV absorbance at 280 nm
    Immunogène
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein.
    Isotype
    IgG
  • Indications d'application
    This affinity purified antibody has been tested for use in ELISA, western blotting, and immunoprecipitation.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 42 kDa in size corresponding to Tamalin protein by western blotting in the appropriate cell lysate or extract.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.03 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
  • Kimura, Kitano, Nakajima, Nakanishi: "Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 9, Issue 7, pp. 631-40, (2004) (PubMed).

    Hirose, Kitano, Nakajima, Moriyoshi, Yanagi, Yamamura, Muto, Jingami, Nakanishi: "Phosphorylation and recruitment of Syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin." dans: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32308-15, (2004) (PubMed).

    Kitano, Nishida, Itsukaichi, Minami, Ogawa, Hirano, Mori, Nakanishi: "Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Cav2.1 Ca2+ channel." dans: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 25101-8, (2003) (PubMed).

    Kitano, Kimura, Yamazaki, Soda, Shigemoto, Nakajima, Nakanishi: "Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 4, pp. 1280-9, (2002) (PubMed).

  • Antigène
    Tamalin/GRASP (GRASP) (GRP1 (General Receptor For phosphoinositides 1)-Associated Scaffold Protein (GRASP))
    Autre désignation
    Tamalin (GRASP Produits)
    Synonymes
    GRASP, tamalin, TAMALIN, general receptor for phosphoinositides 1 associated scaffold protein, GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein, GRASP, grasp, Grasp
    Sujet
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domain-containing protein that interacts with group 1 metabotropic glutamate receptors (mGluRs).  The PDZ domain-containing amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs.  The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins.  Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins.  It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.
    Synonyms: DXImx47e antibody, GRASP 1 antibody, GRIP 1 associated protein 1 antibody, GRIP associated protein 1 antibody, GRIP1 associated protein 1 antibody, GRIPAP 1 antibody, General receptor for phosphoinositides 1-associated scaffold protein
    ID gène
    56149, 103472019
    UniProt
    Q9JJA9
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