TAF1 anticorps (C-Term)

N° du produit ABIN233826

Détail du produit anti-TAF1 anticorps

Antigène: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TAF1 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Souris, Rat (Rattus)

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the of human TAF1.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 213 kDa in size corresponding to TAF1 protein by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.15 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-TAF1 (ABIN233826)

Gegonne, Tai, Zhang, Wu, Zhu, Yoshimoto, Hanson, Cultraro, Chen, Guinter, Yang, Hathcock, Singer, Rodriguez-Canales, Tessarollo, Mackem, Meerzaman, Buetow, Singer: "The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells." dans: Molecular and cellular biology, Vol. 32, Issue 10, pp. 1984-97, (2012) (PubMed).

Détails sur TAF1

Antigène: TAF1 (TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa (TAF1))

Autre désignation: TAF1 (TAF1 Produits)

Synonymes: anticorps BG:DS00004.13, anticorps CG17603, anticorps Dmel\\CG17603, anticorps EfW1, anticorps SR3-5, anticorps TAF, anticorps TAF1, anticorps TAF200, anticorps TAF230, anticorps TAF250, anticorps TAF250/230, anticorps TAFII-250, anticorps TAFII250, anticorps TAF[II]250, anticorps TAF[[II]], anticorps TAF[[II]]230, anticorps TAF[[II]]250, anticorps TAF[[II]]250/230, anticorps TFIID, anticorps TFIID TAF250, anticorps Taf1p, anticorps Taf200, anticorps Taf230, anticorps Taf250, anticorps Taf[[II]]250, anticorps cel, anticorps cell, anticorps d230, anticorps dTAF230, anticorps dTAF250, anticorps dTAFII250, anticorps dTAF[[II]]230, anticorps dTAF[[II]]250, anticorps dmTAF1, anticorps dmTAF[[II]]230, anticorps l(3)84Ab, anticorps p230, anticorps 250kDa, anticorps AU015687, anticorps B430306D02Rik, anticorps Ccg-1, anticorps Ccg1, anticorps KAT4, anticorps N-TAF1, anticorps Taf2a, anticorps RGD1562050, anticorps BA2R, anticorps CCG1, anticorps CCGS, anticorps DYT3, anticorps DYT3/TAF1, anticorps NSCL2, anticorps OF, anticorps P250, anticorps TAF2A, anticorps XDP, anticorps TAF(II)250, anticorps p250, anticorps TBP-associated factor 1, anticorps TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa, anticorps transcription initiation factor TFIID subunit 1, anticorps transcription initiation factor TFIID, subunit TAF1, anticorps TATA-box binding protein associated factor 1, anticorps Taf1, anticorps TAF1, anticorps LOC5567420, anticorps CpipJ_CPIJ003658, anticorps TAF11.1, anticorps HAF1501, anticorps HAF1502, anticorps LOC100457071

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Transcription Initiation Factor TFIID Subunit 1 (TAF1) is the largest component and core scaffold of the TFIID basal transcription factor complex, which also includes TATA-binding protein (TBP) and a variety of TBP-associated factors.  TFIID nucleates the formation of transcription pre-initiation complexes and plays a key role in the regulation of gene expression by RNA polymerase II.  TAF1 possesses DNA-binding activity and also contains novel N- and C-terminal Ser/Thr kinase domains which can auto-phosphorylate or trans-phosphorylate other transcription factors. For example, TAF1 interacts with the C-terminus of TP53 and phosphorylates the T55 residue, leading to MDM2-mediated degradation of TP53.  TAF1 also catalyzes Ser phosphorylation of general transcription factor IIA (GTF2A1) and IIF (GTF2F1).  The retinoblastoma tumor suppressor protein, RB1, interacts with the N-terminal domain of TAF1 and inhibits its intrinsic kinase activity.  TAF1 is essential for progression through the G1 phase of the cell cycle and has been reported to be indispensable for expression of 18% of mammalian genes.
Synonyms: Transcription Initiation Factor TFIID Subunit 1, TAF1

ID gène: 6872, 115942

UniProt: B1Q2X3