s100a4 anticorps

N° du produit ABIN238333

Détail du produit anti-s100a4 anticorps

Antigène: s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp s100a4 est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: Protein G

Immunogène: genetic immunisation with cDNA encoding S100 A4

Clone: NJ-4F3

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: 1.2 µg/10^6 cells
CELISA: 1:200 - 1:400
ELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Stockage

Buffer: PBS, pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C

Stockage commentaire: short term: 2 °C - 8 °C, long term: -20 °C

Détails sur s100a4

Antigène: s100a4 (S100A4) (S100 Calcium Binding Protein A4 (S100A4))

Autre désignation: S100A4 (S100A4 Produits)

Synonymes: anticorps 18A2, anticorps 42A, anticorps CAPL, anticorps FSP1, anticorps MTS1, anticorps P9KA, anticorps PEL98, anticorps 42a, anticorps Capl, anticorps FSp1, anticorps Mts1, anticorps PeL98, anticorps metastasin, anticorps pk9a, anticorps S100A4, anticorps P9ka, anticorps RNP9KA, anticorps S100 calcium binding protein A4, anticorps S100 calcium-binding protein A4, anticorps S100A4, anticorps S100a4

Sujet: S100 calcium binding protein A4 (S100A4) is a member of the S100 family of calcium-binding proteins that contain two Ca(2+)-binding sites including a canonical EF-hand motif. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells. S100A4 interacts with cytoskeletal proteins and enhances metastasis of several types of cancer cells. It is secreted by unknown mechanisms, thus, paracrinely stimulating a variety of cellular responses, including angiogenesis and neuronal growth. S100A4 has been shown to be a prognostic marker in a number of human cancers, including esophageal-squamous cancers, non-small lung cancers, primary gastric cancers, malignant melanomas, prostate cancers, bladder cancers, and pancreatic carcinomas. The universality of S100A4 expression in a variety of cancers illustrates the potential use of S100A4 as a marker for tumor metastasis and disease progression.

UniProt: P26447

Pathways: S100 Proteins