Nephrin anticorps

N° du produit ABIN2426273

Détail du produit anti-Nephrin anticorps

Antigène: Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Nephrin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Affinity purification

Immunogène: Synthetic peptide of human NPHS1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:25-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Nephrin

Antigène: Nephrin (NPHS1) (Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1))

Autre désignation: NPHS1 (NPHS1 Produits)

Synonymes: anticorps NPHS1, anticorps nphs1l, anticorps nphs1, anticorps CNF, anticorps NPHN, anticorps nephrin, anticorps NephrinB, anticorps NPHS1, nephrin, anticorps nephrosis 1, congenital, Finnish type (nephrin), anticorps NPHS1 nephrin S homeolog, anticorps nephrin, anticorps NPHS1 nephrin, anticorps nephrosis 1, nephrin, anticorps NPHS1, anticorps nphs1, anticorps nphs1.S, anticorps LOC5579127, anticorps Nphs1

Sujet: CNF,Nephrin,Nephrosis 1 congenital Finnish type,Nephrosis 1,congenital,Finnish type (nephrin),NPHN,NPHN,NPHS 1,Nphs1,Renal glomerulus specific cell adhesion receptor,Renal glomerulus-specific cell adhesion receptor,This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180- kDa protein in lysates of human glomeruli and a 150- kDa protein in transfected COS-7 cell lysates.

Poids moléculaire: Calculated MW: 135 kDa

NCBI Accession: NP_004637

Pathways: Regulation of Actin Filament Polymerization, Skeletal Muscle Fiber Development