AVEN anticorps

N° du produit ABIN2431089

Détail du produit anti-AVEN anticorps

Antigène: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AVEN est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Synthetic peptide of human AVEN

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:25-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur AVEN

Antigène: AVEN (Apoptosis, Caspase Activation Inhibitor (AVEN))

Autre désignation: AVEN (AVEN Produits)

Synonymes: anticorps AVEN, anticorps pdcd12, anticorps aven, anticorps wu:fc08c09, anticorps si:ch211-150c22.4, anticorps PDCD12, anticorps 1700013A01Rik, anticorps 1700056A21Rik, anticorps mAven-L, anticorps mAven-S, anticorps apoptosis and caspase activation inhibitor, anticorps apoptosis, caspase activation inhibitor L homeolog, anticorps apoptosis, caspase activation inhibitor, anticorps Aven, anticorps AVEN, anticorps aven.L, anticorps aven

Sujet: AVEN, a cell death regulator, is an important signal inducer in acute leuke-mias. AVEN is a highly conserved peripheral membrane protein that protects the cell against the proteolytic activation of caspases as well as Apaf-1 mediated apoptosis by interfering with Apaf-1's ability to self-associate. Bcl-2 and Bad also interact with AVEN to prevent apoptosis. AVEN is highly expressed in ovary, heart, thymus, spleen, testis and colon, but can also be detected in other tissues. Erythropoietin and methylprednisolone may play important roles in the expression of AVEN in cardiac tissue, especially after a traumatic brain injury. In young patients suffering from acute lymphoblastic leukemia (ALL), AVEN expression may be a useful tool in prognosis prediction.

Poids moléculaire: Calculated MW: 39 kDa

NCBI Accession: NP_065104