PTAFR anticorps

N° du produit ABIN2432185

Détail du produit anti-PTAFR anticorps

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTAFR est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Synthetic peptide of human PTAFR

Isotype: IgG

Information d'application

Indications d'application: IHC 1:25-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Agent conservateur: Sodium azide

Conseil sur la manipulation: Avoid freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur PTAFR

Antigène: PTAFR (Platelet-Activating Factor Receptor (PTAFR))

Autre désignation: PTAFR (PTAFR Produits)

Synonymes: anticorps PAFR, anticorps MGC52896, anticorps MGC160177, anticorps PAFr, anticorps pafr, anticorps PAF-R, anticorps platelet activating factor receptor, anticorps platelet-activating factor receptor, anticorps platelet activating factor receptor L homeolog, anticorps PTAFR, anticorps Ptafr, anticorps ptafr.L, anticorps ptafr

Sujet: This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.

NCBI Accession: NP_000943

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin