Presenilin 2 anticorps (AA 34-45)

N° du produit ABIN2443734

Cet anticorps anti-Presenilin 2 Monoclonal Souris (Clone APS21) (ABIN2443734) détecte spécifiquement Presenilin 2 dans WB, ELISA et IF. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Presenilin 2 anticorps (AA 34-45) (ABIN2443734)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Humain, Rat, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: APS21

Détail du produit anti-Presenilin 2 anticorps

Épitope: AA 34-45

Fonction: Presenilin 2 (C term) Mouse Monoclonal Antibody (APS21)

Specificité: The antibody recognizes the C-terminal region of Presenilin 2 with no cross-reactivity observed with Presenilin 1.

Immunogène: aa 34-45

Isotype: IgG1

Information d'application

Indications d'application: ELISA 1:1000,WB 1:100,IF 1:1300,IHC 1:1300

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: If reconstituted with deionized water in 250μL: ELISA 1:1000, WB 1:100, IF 1:1300, IHC 1:1300. Optimal dilution has to be determined by the user.

Buffer: Lyophilized protein free tissue culture supernatant

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Lyophilized antibodies can be kept at 4°C for up to 3 months and should be kept at -20°C for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80°C) or kept at 4°C for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy. To limit antibody loss or degradation, BSA (final concentration 1%) and sodium azide (final concentration 0.02%) can be added to the suggested first dilution. It is important to first verify if those preservatives are compatible with your assay.

Date de péremption: 24 months

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: Presenilin 2

Sujet:

PS-2, AD3LP, AD5, E5-1, STM-2, PSEN2

Presenilin is an integral membrane protein ubiquitously expressed in the brain, it is mainly expressed in neurons where it is localized in the endoplasmic reticulum. Mutations in the presenilin proteins (PSEN1, PSEN2) are linked to an inherited form of Alzheimer's disease in some patients by increasing the production of the longer form of amyloid-beta. Presenilins are thought to affect gamma-secretase by regulating amyloid precursor protein (APP) processing and cleavage of the Notch receptor.

UniProt: P49810

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway