ING3 anticorps

N° du produit ABIN2458018

Détail du produit anti-ING3 anticorps

Antigène: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ING3 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ING3.

Information d'application

Indications d'application: ING3 antibody can be used for detection of ING3 by ELISA at 1:62500. ING3 antibody can be used for detection of ING3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store ING3 antibody at -20 °C.

Détails sur ING3

Antigène: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Autre désignation: ING3 (ING3 Produits)

Synonymes: anticorps ING3, anticorps Eaf4, anticorps ING2, anticorps MEAF4, anticorps p47ING3, anticorps 1300013A07Rik, anticorps P47ING3, anticorps zgc:56327, anticorps inhibitor of growth family member 3, anticorps inhibitor of growth family, member 3, anticorps inhibitor of growth protein 3, anticorps inhibitor of growth family member 3 L homeolog, anticorps ING3, anticorps Ing3, anticorps CpipJ_CPIJ009396, anticorps ing3, anticorps ing3.L

Sujet: ING3 is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers.The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Poids moléculaire: 47 kDa

ID gène: 54556

NCBI Accession: NP_061944

UniProt: Q9NXR8