GP6 anticorps

N° du produit ABIN2459082

Détail du produit anti-GP6 anticorps

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GP6 est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GP6.

Information d'application

Indications d'application: GP6 antibody can be used for detection of GP6 by ELISA at 1:1562500. GP6 antibody can be used for detection of GP6 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GP6 antibody at -20 °C.

Détails sur GP6

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Autre désignation: GP6 (GP6 Produits)

Synonymes: anticorps BDPLT11, anticorps GPIV, anticorps GPVI, anticorps 9830166G18Rik, anticorps Gm469, anticorps Gpvi, anticorps GP6, anticorps glycoprotein VI platelet, anticorps glycoprotein 6 (platelet), anticorps glycoprotein VI, anticorps platelet glycoprotein VI, anticorps GP6, anticorps Gp6, anticorps LOC103346235

Sujet: Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].

Poids moléculaire: 37 kDa

ID gène: 51206

NCBI Accession: NP_057447

UniProt: Q9HCN6