LMX1A anticorps

N° du produit ABIN2460346

Détail du produit anti-LMX1A anticorps

Antigène: LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LMX1A est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human LMX1A.

Information d'application

Indications d'application: LMX1A antibody can be used for detection of LMX1A by ELISA at 1:62500. LMX1A antibody can be used for detection of LMX1A by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store LMX1A antibody at -20 °C.

Détails sur LMX1A

Antigène: LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))

Autre désignation: LMX1A (LMX1A Produits)

Synonymes: anticorps Lmx1.1, anticorps dr, anticorps dreher, anticorps sst, anticorps LMX1, anticorps LMX1.1, anticorps si:ch211-260g14.3, anticorps LIM homeobox transcription factor 1 alpha, anticorps LIM homeobox transcription factor 1, alpha, anticorps Lmx1a, anticorps LMX1A, anticorps lmx1a

Sujet: Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 AL160058.8 14249-14447 c 200-2447 AK127724.1 362-2609 2448-3382 AL390730.12 9415-10349 c

Poids moléculaire: 43 kDa

ID gène: 4009

NCBI Accession: NP_796372

UniProt: Q8TE12

Pathways: Dopaminergic Neurogenesis