SFPQ anticorps

N° du produit ABIN2462181

Détail du produit anti-SFPQ anticorps

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SFPQ est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antibody is purified by protein A chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SFPQ.

Information d'application

Indications d'application: SFPQ antibody can be used for detection of SFPQ by ELISA at 1:12500. SFPQ antibody can be used for detection of SFPQ by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SFPQ antibody at -20 °C.

Détails sur SFPQ

Antigène: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Autre désignation: SFPQ (SFPQ Produits)

Synonymes: anticorps 1110004P21Rik, anticorps 2810416M14Rik, anticorps 5730453G22Rik, anticorps 9030402K04Rik, anticorps AU021830, anticorps D4Ertd314e, anticorps Gm12940, anticorps OTTMUSG00000009329, anticorps PSF, anticorps REP1, anticorps hm:zeh0027, anticorps wu:fa11h12, anticorps wu:fd10f03, anticorps zgc:85935, anticorps POMP100, anticorps splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated), anticorps splicing factor proline/glutamine-rich, anticorps splicing factor proline and glutamine rich, anticorps Sfpq, anticorps sfpq, anticorps SFPQ

Sujet: SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as an heteromer with NONO. It binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. It interacts with U5 snRNA. It may be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. SFPQ may be involved in homologous DNA pairing. SFPQ is involved in transcriptional regulation. It binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity.

Poids moléculaire: 78 kDa

ID gène: 6421

NCBI Accession: NP_005057

UniProt: P23246