PTPRR anticorps

N° du produit ABIN2462848

Détail du produit anti-PTPRR anticorps

Antigène: PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPRR est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human PTPRR.

Information d'application

Indications d'application: PTPRR antibody can be used for detection of PTPRR by ELISA at 1:62500. PTPRR antibody can be used for detection of PTPRR by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store PTPRR antibody at -20 °C.

Détails sur PTPRR

Antigène: PTPRR (Protein tyrosine Phosphatase, Receptor Type, R (PTPRR))

Autre désignation: PTPRR (PTPRR Produits)

Synonymes: anticorps EC-PTP, anticorps PCPTP1, anticorps PTP-SL, anticorps PTPBR7, anticorps PTPRQ, anticorps Pcptp1, anticorps ec-ptp, anticorps pcptp1, anticorps ptp-sl, anticorps ptpbr7, anticorps PTPRR, anticorps Gmcp1, anticorps RPTPRR, anticorps mPTP213, anticorps protein tyrosine phosphatase, receptor type R, anticorps protein tyrosine phosphatase, receptor type, R, anticorps protein tyrosine phosphatase, receptor type R L homeolog, anticorps protein tyrosine phosphatase, receptor type, r, anticorps receptor-type tyrosine-protein phosphatase R, anticorps PTPRR, anticorps Ptprr, anticorps ptprr.L, anticorps ptprr, anticorps LOC100715069

Sujet: PTPRR is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominately expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Mutations in this gene cause autosomal dominant dyskeratosis congenita, and may also be associated with some cases of aplastic anemia.

Poids moléculaire: 46 kDa, 74 kDa

ID gène: 5801

NCBI Accession: NP_570897

UniProt: Q7Z2V8