SREBF1 anticorps

N° du produit ABIN2463722

Détail du produit anti-SREBF1 anticorps

Antigène: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SREBF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SREBF1.

Information d'application

Indications d'application: SREBF1 antibody can be used for detection of SREBF1 by ELISA at 1:62500. SREBF1 antibody can be used for detection of SREBF1 by western blot at 0.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store SREBF1 antibody at -20 °C.

Détails sur SREBF1

Antigène: SREBF1 (Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))

Autre désignation: SREBF1 (SREBF1 Produits)

Synonymes: anticorps SREBP-1c, anticorps SREBP1, anticorps bHLHd1, anticorps ADD-1, anticorps ADD1, anticorps D630008H06, anticorps SREBP-1, anticorps SREBP-1a, anticorps SREBP1c, anticorps Srebp1, anticorps SCREBP1, anticorps SREBP-1C, anticorps SREBF1, anticorps srebp1, anticorps sterol regulatory element binding transcription factor 1, anticorps sterol regulatory element binding transcription factor 1 L homeolog, anticorps sterol regulatory element binding protein-1, anticorps Sterol regulatory element Binding Protein, anticorps SREBF1, anticorps Srebf1, anticorps srebf1.L, anticorps SREBP-1, anticorps srebf1, anticorps sbp-1

Sujet: SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 125 kDa

ID gène: 6720

NCBI Accession: NP_001005291

UniProt: P36956

Pathways: AMPK Signaling, Caspase Cascade in Apoptosis, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha