H1FOO anticorps

N° du produit ABIN2463933

Détail du produit anti-H1FOO anticorps

Antigène: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp H1FOO est non-conjugé

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogène: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human H1FOO.

Information d'application

Indications d'application: H1FOO antibody can be used for detection of H1FOO by ELISA at 1:312500. H1FOO antibody can be used for detection of H1FOO by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Conseil sur la manipulation: As with any antibody avoid repeat freeze-thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: For short periods of storage (days) store at 4 °C. For longer periods of storage, store H1FOO antibody at -20 °C.

Détails sur H1FOO

Antigène: H1FOO (H1 Histone Family, Member O, Oocyte-Specific (H1FOO))

Autre désignation: H1FOO (H1FOO Produits)

Synonymes: anticorps osH1, anticorps C86609, anticorps H1fo, anticorps H1oo, anticorps b4, anticorps RGD1566236, anticorps H1 histone family member O oocyte specific, anticorps H1 histone family, member O, oocyte-specific, anticorps H1 histone family member O oocyte specific S homeolog, anticorps H1FOO, anticorps H1foo, anticorps h1foo.S

Sujet: H1FOO may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. H1FOO is essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The protein encoded is a member of the histone H1 family. The related mouse gene is expressed only in oocytes.

Poids moléculaire: 36 kDa

ID gène: 132243

NCBI Accession: NP_722575

UniProt: Q8IZA3