ALDH7A1
Reactivité: Humain, Souris, Rat
IF
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
PDE antibody can be used for detection of PDE by ELISA at 1:1562500. PDE antibody can be used for detection of PDE by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
Concentration
1 mg/mL
Buffer
Antibody is lyophilized in PBS buffer with 2 % sucrose.
Conseil sur la manipulation
As with any antibody avoid repeat freeze-thaw cycles.
Stock
4 °C/-20 °C
Stockage commentaire
For short periods of storage (days) store at 4 °C. For longer periods of storage, store PDE antibody at -20 °C.
Antigène
ALDH7A1
(Aldehyde Dehydrogenase 7 Family, Member A1 (ALDH7A1))
anticorps atq1, anticorps ALDH7A1, anticorps ATQ1, anticorps EPD, anticorps PDE, anticorps antiquitin, anticorps ATQ, anticorps wu:fi34d12, anticorps wu:fi35e06, anticorps Atq1, anticorps D18Wsu181e, anticorps aldehyde dehydrogenase 7 family member A1, anticorps aldehyde dehydrogenase 7 family member A1 L homeolog, anticorps aldehyde dehydrogenase 7 family, member A1, anticorps aldehyde dehydrogenase family 7, member A1, anticorps ALDH7A1, anticorps aldh7a1, anticorps aldh7a1.L, anticorps Aldh7a1
Sujet
2'-PDE is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. 2'-PDE also cleaves 3',5'-phosphodiester bond of oligoadenylates. 2'-PDE play a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.