GPR37 anticorps (N-Term)

N° du produit ABIN2469255

Détail du produit anti-GPR37 anticorps

Antigène: GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))

Épitope: N-Term

Reactivité: Humain, Gorilla, Gibbon

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GPR37 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Specificité: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogène: PAEL Receptor antibody was raised against a peptide located in the N-Terminal extracellular domain of PAEL Receptor (Human).

Information d'application

Indications d'application: PAEL Receptor antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-80 °C

Stockage commentaire: PAEL Receptor antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Détails sur GPR37

Antigène: GPR37 (G Protein-Coupled Receptor 37 (Endothelin Receptor Type B-Like) (GPR37))

Abstract: GPR37 Produits

Synonymes: anticorps ACCA, anticorps EDNRBL, anticorps PAELR, anticorps hET(B)R-LP, anticorps AI848630, anticorps Pael-R, anticorps Ednrbl, anticorps G protein-coupled receptor 3, anticorps G protein-coupled receptor 37, anticorps GPR3, anticorps GPR37, anticorps Gpr37

Sujet: GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.

ID gène: 2861

UniProt: O15354