ATRX anticorps (C-Term)

N° du produit ABIN2469774

Détail du produit anti-ATRX anticorps

Antigène: ATRX (helicase 2, X-linked (ATRX))

Épitope: C-Term

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATRX est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Protein G Column

Immunogène: ATRX monoclonal antibody was raised against peptides from the C-Terminus of ATRX (Human).

Clone: 60-1

Isotype: IgG

Information d'application

Indications d'application: ATRX antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.2. No preservatives added.

Agent conservateur: Without preservative

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Store ATRX antibody at -20 °C.

Détails sur ATRX

Antigène: ATRX (helicase 2, X-linked (ATRX))

Autre désignation: ATRX (ATRX Produits)

Synonymes: anticorps ATR2, anticorps JMS, anticorps MRXHF1, anticorps RAD54, anticorps RAD54L, anticorps SFM1, anticorps SHS, anticorps XH2, anticorps XNP, anticorps ZNF-HX, anticorps 4833408C14Rik, anticorps AI447451, anticorps DXHXS6677E, anticorps HP1-BP38, anticorps Hp1bp2, anticorps Hp1bp38, anticorps MRXS3, anticorps Rad54, anticorps Xnp, anticorps atrx, anticorps rad54, anticorps atrxl, anticorps wu:fb26e12, anticorps wu:fb52h08, anticorps wu:fb72g09, anticorps wu:fb94e07, anticorps zgc:66223, anticorps ATRX, chromatin remodeler, anticorps alpha thalassemia/mental retardation syndrome X-linked L homeolog, anticorps alpha thalassemia/mental retardation syndrome X-linked homolog (human), anticorps ATRX, anticorps Atrx, anticorps atrx.L, anticorps atrx

Sujet: The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

ID gène: 546

UniProt: P46100