HSP90B2P anticorps (AA 289-300)

N° du produit ABIN2470237

Détail du produit anti-HSP90B2P anticorps

Antigène: HSP90B2P (Heat Shock Protein 90kDa beta (Grp94), Member 2, Pseudogene (HSP90B2P))

Épitope: AA 289-300

Reactivité: Humain, Souris, Rat, Poulet, Drosophila melanogaster, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HSP90B2P est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Immunoaffinity Chromatography

Immunogène: HSP90B2P antibody was raised against amino acids 289-300 of HSP90B2P (Human).

Information d'application

Indications d'application: HSP90B2P antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 - 10 μg/mL, immunoprecipitation, and flow cytometry.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: As with all antibodies avoid freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store HSP90B2P antibody at 4 °C or -20 °C.

Détails sur HSP90B2P

Antigène: HSP90B2P (Heat Shock Protein 90kDa beta (Grp94), Member 2, Pseudogene (HSP90B2P))

Autre désignation: HSP90B2P (HSP90B2P Produits)

Synonymes: anticorps GRP94P1, anticorps GRP94b, anticorps HSP, anticorps HSPCP2, anticorps TRA1P1, anticorps TRAP1, anticorps heat shock protein 90 beta family member 2, pseudogene, anticorps HSP90B2P

Sujet: Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.

ID gène: 3320

UniProt: P07900