AKAP12 anticorps (AA 620-1596)

N° du produit ABIN264964

Cet anticorps Mouton Polyclonal détecte spécifiquement AKAP12 dans WB, IP et IHC (fro). Il présente une réactivité envers Rat et Boeuf (Vache).

Aperçu rapide pour AKAP12 anticorps (AA 620-1596) (ABIN264964)

Antigène: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Reactivité: Rat, Boeuf (Vache)

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp AKAP12 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-AKAP12 anticorps

Épitope: AA 620-1596

Purification: Ammonium Sulfate Precipitation.

Immunogène: Recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 2-5 μg/mL. Immunoprecipitation. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline with 0.08 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Détails sur AKAP12

Antigène: AKAP12 (A Kinase (PRKA) Anchor Protein 12 (AKAP12))

Autre désignation: AKAP12 / SSeCKS

Sujet: Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicatedduring the process of spermiogenesis and in the actinbased stellate morphology of mesangial cells.

ID gène: 10116

UniProt: Q62766

Pathways: cAMP Metabolic Process