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VSX2 anticorps (Visual System Homeobox 2) (C-Term) Primary Antibody

VSX2 Reactivité: Souris, Rat IHC (fro), WB Hôte: Mouton Polyclonal
Pubmed (5)
N° du produit ABIN265010
$500.50
Plus shipping costs $45.00
0.25 mg
local_shipping Destination: Etats-Unis
Envoi sous 6 à 8 jours ouvrables
  • Antigène
    Épitope
    AA 264-361, C-Term
    Reactivité
    Souris, Rat
    Hôte
    Mouton
    Clonalité
    Polyclonal
    Conjugué
    Cet anticorp VSX2 est non-conjugé
    Application
    Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
    Specificité
    This antibody recognizes chx 10 (C-Term). Other species not tested.
    Purification
    Purified
    Immunogène
    Antibody raised against a recombinant protein corresponding to amino acids 264 to 361 derived from the C terminal of the human Chx10 protein conjugated to GST.
    Isotype
    IgG
  • Indications d'application
    Western Blot: 0.5-1.0 mg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    PBS containing 0.08 % Sodium Azide as preservative.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
    Stockage commentaire
    Store the antibody (in aliquots) at -20 °C. Can be shipped at ambient temperature.
  • Francius, Harris, Rucchin, Hendricks, Stam, Barber, Kurek, Grosveld, Pierani, Goulding, Clotman: "Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord." dans: PLoS ONE, Vol. 8, Issue 8, pp. e70325, 2013 (PubMed).

    Nittner, Lambertz, Clermont, Mestdagh, Köhler, Nielsen, Jochemsen, Speleman, Vandesompele, Dyer, Schramm, Schulte, Marine: "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." dans: Nature cell biology, Vol. 14, Issue 9, pp. 958-65, 2012 (PubMed).

    Qiu, Jiang, Xiang: "A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 13, pp. 3392-403, 2008 (PubMed).

    Elshatory, Everhart, Deng, Xie, Barlow, Gan: "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 46, pp. 12707-20, 2007 (PubMed).

    Osakada, Ooto, Akagi, Mandai, Akaike, Takahashi: "Wnt signaling promotes regeneration in the retina of adult mammals." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 15, pp. 4210-9, 2007 (PubMed).

  • Antigène
    Autre désignation
    VSX2 / CHX10 (VSX2 Antibody Extrait)
    Synonymes
    CHX10, HOX10, MCOP2, MCOPCB3, RET1, Chx10, Hox-10, Hox10, or, VSX2, Vsx-2, alx, chx10, visual system homeobox 2, Vsx2 transcription factor, VSX2, Vsx2, vsx2
    Sujet
    Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.Synonyms: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2
    Poids moléculaire
    46 kDa
    ID gène
    12677
    NCBI Accession
    NP_031727
    UniProt
    Q61412
    Pathways
    Dopaminergic Neurogenesis
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