PPAPDC2 anticorps

N° du produit ABIN265121

Détail du produit anti-PPAPDC2 anticorps

Antigène: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPAPDC2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2).

Purification: Affinity Purified

Immunogène: Synthetic peptide derived from human phosphatidic acid phosphatase type 2 domain containing 2 (PPAPDC2)

Information d'application

Indications d'application: Western Blot: 1: 400 - 1: 800. Positive Control: Testis.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Ship on gel ice. Store (in aliquots) at -20 °C only.

Détails sur PPAPDC2

Antigène: PPAPDC2 (Phosphatidic Acid Phosphatase Type 2 Domain Containing 2 (PPAPDC2))

Autre désignation: PPAPDC2 (PPAPDC2 Produits)

Synonymes: anticorps PPAPDC2, anticorps PDP1, anticorps PSDP, anticorps bA6J24.6, anticorps 4932443D16Rik, anticorps phospholipid phosphatase 6, anticorps PLPP6, anticorps plpp6, anticorps Plpp6

Sujet: Upon cell activation Presqualene diphosphate (PSDP)2, a bioactive lipid, rapidly remodels to presqualene monophosphate (PSMP). A newly identified and characterized phosphatase (phosphatidic acid phosphatase domain containing 2 (PPAPDC2)) has recent,y been shown to convert PSDP to PSMP. Unlike the related polyisoprenyl phosphate farnesyl diphosphate (FDP), PSDP has been shown not to be a substrate for type 2 lipid phosphate phosphohydrolases. PSDP phosphatase activity has been identified in activated human neutrophil (PMN) extracts. Recombinant PPAPDC2 displays diphosphate phosphatase activity with substrate preference for PSDP > FDP phosphatidic acid. PPAPDC2 activity is independent of Mg2+ and optimal at pH 7.0 - 8.0. PPAPDC2 mRNA has been detected in human PMN, and is widely expressed in human tissues. PPAPDC2 expressed in human PMN is first lipid phosphate phosphohydrolase identified for PSDP. The regulation of this enzymes activity has important implications for PMN activation in innate immunity.Synonyms: PPAP2 domain-containing protein 2, Phosphatidic acid phosphatase type 2 domain-containing protein 2, Presqualene diphosphate phosphatase

ID gène: 403313

NCBI Accession: NP_982278

UniProt: Q8IY26